A new generation of sequence-specific probes designed using LNA (a novel nucleic acid analogue), which enhances hybridization performance and biological stability (Koch, 2003; Tolstrup, 2003; Johnson, 2004). Besides increased specificity and stability, by allowing shorter probes, LNA increases quenching efficiency and reduces signal-to-noise ratio. LNA probes perform similar to MGB probes (Letertre, 2003; Johnson, 2004). LNA is also used in primers to increase sensitivity (Latorra, 2003). See web brochures by Exiqon; Thermo; Eurogentec; IDT; Gene Link; PCR: Replicating Success (Moore, 2005) and Simplifying the Probe Set (Mouritzen, 2005).